Centros de Histocompatibilidade

Os Centros de Histocompatibilidade do Norte, do Centro e do Sul foram integrados no Administrações Regionais de Saúde, IP do Norte, Centro e Lisboa e Vale do Tejo, respectivamente. Eles foram agrupados funcionalmente a nível nacional, mantendo, para o efeito, um nome comum para Lusotransplante.

  • Realizam estudos laboratoriais de imunogenética, imunobiologia e das doenças transmissíveis, aplicados à transplantação de órgãos, tecidos e células, em dadores e receptores, nos períodos pré e pós-transplantação.
  • Mantêm o registo nacional de dadores voluntários de medula óssea, designado CEDACE – Centro Nacional de Dadores de Células de Medula Óssea, Estaminais ou de Sangue do Cordão, bem como a actividade de Centro de Dadores na respectiva área de influência.
  • Asseguram a manutenção e actualização da base de dados de âmbito nacional, necessária para o seguimento dos doentes pré e pós-transplantados, bem como a escolha do par dador-receptor em transplantação renal.
  • Asseguram a gestão da lista de espera para transplantação renal.
  • Desenvolvem a actividade de investigação no âmbito da transplantação de órgãos, tecidos e células e medicina regenerativa.
  • Desenvolvem a criopreservação de tecidos e células para transplantação.
  • Mantêm um arquivo biológico de doentes e dadores.

Harmony Harmony
The south transplant center, used this website?

Megan Megan
O centro de transplante do Sul, usou esse site?

Tyler Tyler
Previously yes, but not anymore. This website is undergoing redevelopment.

David David
Anteriormente, sim, mas não agora. Este site está passando por remodelação

 
 


Histocompatibility Centers

The Centers for Histocompatibility North, Central and South were in the Regional Health Administrations: North, Central and South/Lisbon. They had a common function nationally, for organ transplantation.

  • Perform laboratory studies of immunogenetics, immunobiology and communicable diseases, applied to the transplantation of organs, tissues and cells in donors and recipients, pre and post transplant.
  • Maintain the national registry of volunteer bone marrow donors, designated CEDACE – National Center Donor Bone Marrow Cells, Stem or Cord Blood as well as the activity of Donor Centers.
  • Maintain and update the national database, required for the monitoring of pre and post – transplant patients, as well as the choice of the donor-recipient pairs in renal transplantation.
  • Management of the waiting list for kidney transplantation.
  • Develop research activity within the transplantation of organs, tissues and cells and regenerative medicine.
  • Developing cryopreservation of tissues and cells for transplantation.
  • Maintain a file of patients and biological donors.

Contactos: / Contacts:
Megan Megan
I don’t think any of these websites or centers exist anymore.

Harmony Harmony
Eu não acho que qualquer um desses sites ou centros existe mais.

 
 

Centro de Histocompatibilidade do Norte
Rua Dr. Roberto Frias – Pav. “Maria Fernanda”
4200-465 PORTO
Telefone: 225573470

Centro de Histocompatibilidade do Centro
Praceta Prof. Mota Pinto, Edif. S. Jerónimo, 4.º piso
Apartado 9041
3001-301 COIMBRA
Telefone: 239480700

Centro de Histocompatibilidade do Sul
Alameda das Linhas de Torres, n.º 117
1769-001 LISBOA
Telefone: 217504100


Harmony Harmony
This was an important website. What is going to happen with it?

Megan Megan
Este foi um website importante. O que vai acontecer com ele?

David David
It will still contain some transplantation information.

Tyler Tyler
É ainda conterá algumas informações transplante .


 
 


Main Conditions to register as a potential bone marrow donor

  • Between 18 and 45 years
  • Minimum weight of 50kg
  • Taller than 1.5m
  • Be healthy
  • Have never received transfusions after 1980

Exclusions from registering as a Bone Marrow Donor

  • Morbid Obesity, even in cases of placement Band or Gastric Bypass
  • Heart disease
  • Hepatitis B or C, at some time in life
  • Cancer, current or past
  • Autoimmune diseases ( rheumatoid arthritis, lupus )
  • Infectious diseases
  • Renal failure
  • Thyroid Pathology
  • Diabetes
  • Chronic anemia
  • Herniated Disc
  • Fibromyalgia
  • glaucoma
  • Not understand the English language in both its oral and written form
  • Not having established residence in Portugal.

Principais condições para se inscrever como potencial Dador de Medula óssea

  • Ter entre 18 e 45 anos
  • Peso mínimo de 50kg
  • Altura superior a 1,5m
  • Ser saudável
  • Nunca ter recebido transfusões após 1980

Quem não se pode registar como Dador de Medula óssea no Registo Português?
Não poderá registar-se como Dador de Medula Óssea se tiver pelos menos uma das seguintes condições:

  • Obesidade Mórbida, mesmo nos casos de colocação de Banda ou Bypass Gástrico
  • Patologia Cardíaca
  • Hepatite B ou C, alguma vez na vida
  • Doença Oncológica
  • Transfusão de sangue depois de 1980
  • Doenças Auto-imune (Artrite Reumatóide, Lúpus)
  • Doenças infecto-contagiosas
  • Insuficiência renal
  • Patologia da Tiróide
  • Diabetes
  • Anemia Crónica
  • Hérnia Discal
  • Fibromialgia
  • Glaucoma
  • Não compreender a língua portuguesa tanto na sua forma oral como escrita
  • Não ter residência estabelecida em Portugal

Megan Megan
Give us some hints about what is coming.

Harmony Harmony
Dê-nos algumas dicas sobre o que está por vir.


 
 

chsul

transplant chsul donation chsulThis Portuguese website previously had strong links to societies and governmental health agencies that deliver care for renal failure patients, and the attendant health care problems that occur while on transplant waiting lists. The process of donating kidneys, donor issues, compatibility, and so on. Post transplant care and various organizations that are related. As you know, diabetes and heart disease are co-morbidities, and very common diseases in their own right. So there is a lot of medical educational material to cover, in the rejuvenation of this website.

chsul lab

When summer ends, and before you know it, the snow will just be around the corner… Here are some extremely helpful tips on how to Beat Winter Weight Gain. But don’t worry, it’s not time to cuddle up with a blanket and hot cocoa yet… Just keep in mind that this is just an idea of when the time comes, you know, so keep that summer smile on your face :)… for a little while longer at least.


Dr. Halls

My plan is to start by making blog posts from people who have things to say about their transplants and the sometimes heartbreaking things that happen before or after the transplant. And some success stories too, to warm our hearts.


Latest Posts

Overview of the Entire Transplantation of The Kidney.

Transplantation of the kidney is never a real cure. When a patient’s or are in the advanced stage of kidney failure, medical personnel may recommend a transplantation.
When such a patient has a successful transplantation, he/she will be required to take medicine and some types of foods and drinks may be recommended. After the change of the organs, the new kidney will replace the functions of the failed kidneys BUT will require ongoing medication. The advantage of this is that the kidney change and medication to support it are far cheaper than the dialysis option.ei_2597

The transplantation Process.
The transplantation process is a surgical procedure in which the kidney transplant team replaces the failed kidneys with a healthy one into the body of the patient. The new kidney takes the functions of the failed one and also any role which is played by dialysis.
This surgical process may not be recommended to all patients. The medical personnel may rule out transplantation as an option if the condition or infection affecting the kidneys would make the transplantation process dangerous and unsuccessful. But if transplantation is recommended, then a potential donor has to be found.
The new kidney to replace the failed ones can come from two sources/donors:
• Deceased donor &
• Living donor
Deceased donor. This is the leading source of kidney donation. In this instance, a potential donor makes the decision to donate his kidneys in the event of his/her death. There are various organizations which take care of the donations, and the potential donor has to approach any of them with the intention of donating and fill in the necessary documentations. He/she is provided with a card which indicates that incase of one’s death then his/her kidneys are to be taken by the organization concerned with the donations and transplantations.
The number of patients waiting for such donations is high and has been rising in the recent years contrary to the number of potential donors which doesn’t match such growth. This results to the number patient’s waiting list for such kidneys donations to be high.

Living donor. Here, kidneys are donated by family and friends or to some extend well-wisher of the patient. Medical compatibility test has to be carried out to ascertain if the donor’s kidneys will match with the recipients body. Also the potential donor will have to be tested to ensure that the donation won’t endanger the life of the donor.
Living donors help bring down the number of kidneys in the waiting list for those expecting donations from the deceased.
Kidneys from these donors are advantageous over those of the deceased donor because of several reasons as indicated below:
• The patient doesn’t have to spend a lot of money as they wait for kidneys from deceased donors.
• Kidneys from family members are very likely to be compatible.
• Kidneys coming from family members or friends don’t take time to be available. This can significantly reduce the costs of dialysis a patient incurs as he/she waits for a kidney with a perfect match

Before the transplantation process is commenced, a patient has to undergo medical tests at the transplant center. This pre-transplantation evaluation may be scheduled in regular appointments prior to the real process to completely ascertain the success of the real process. Some of the factors evaluated include:
• Blood type and other matching factors that will determine if the patient’s body will accept the new kidney.
• Presence of other complicated diseases like cancer, some advanced cardio-vascular diseases and other serious infections are determined because if present, then the chances of a successful transplantation are minimal.
• The general health of the patient is determined to see if he/she is healthy enough for the surgery.
• In the case of a living donor, he/she will also have to undergo medical evaluations to ascertain that the kidney to be donated will match with the patient’s body and minimize chances of rejection.
• The medical team will also have to counsel the patient of the importance to follow and adhere to post-transplant schedule of medicine given and ensure that the patients fully understands this obligation.
The Real Transplant.
When a kidney matching kidney has been found for a patient in the waiting list or in the case of donation from family, friends or well-wishers, and medical evaluation shows that the patient is a good candidate, then the real procedure is scheduled.
For those in the waiting list, they will have to be ready the very moment that the kidney becomes available. They should visit the transplantation center immediately. Once there, the patient’s blood will be tested for the antibody cross-match test. If the test results negative, it means that the patient’s antibodies won’t react and the transplantation can proceed as scheduled.
Anesthesia is administered to the patient so as to induce sleep throughout the surgical procedure which normally takes 3-4 hours.

The transplantation surgeon will make an incision on the patient’s lower abdomen area. The new kidney will be attached on the patient’s artery and veins with those of the new kidney, while ureter from the new kidney will be attached to the patient’s ureter.
After the process is successfully over and blood flowing through the new kidney, the waste products removal and making of urine will start.
For living donors, the procedure can be scheduled at the most convenient time. When both the patient and the donor are ready, they are operated at the same time in the same transplant center. A team for the transplantation will work on removing the kidney from the donor, a process called nephrectomy, while another team will work on placing the kidney to the recipient.

Post-transplantation care and advice
After a successful transplantation process the recipient will have to take medication to prevent the body from rejecting the new kidney.
The body of a human being has an immune system which can sense any foreign body such as bacteria and work on removing them. This also happens to the new kidney and may cause rejection of the kidney. Medication is therefore given to suppress the immune response from doing so. These drugs are called immunosuppressants. Also other drugs can be introduced to treat other health problems and infections which may arise from the process because immunosuppressants work on reducing the patients immune system thus making one to be susceptible to infections.
The medical team will also recommend the foods which can be taken by the patient but the foods are more favorable than those taken by a person undergoing dialysis e.g. salty foods are supposed to be avoided because they can easily lead to high blood pressure which is a real threat to the new kidney.
Even though a patient adheres to the medication and the recommended foods, the body may still reject the kidney and the patient may have to go back to dialysis or to the waiting list and register for another kidney donation. This is possible only if the body is found still fit for another transplantation.
Therefore after the transplantation process, the patient should look out for signs of the kidney rejections which include:
• Fever.
• Soreness in area of surgery &
• Change in the volume of urine or presence of bloody stains in the urine.
Incase of these signs, the patient should seek medical advice immediately

Basic Overview of Kidney Transplantation

Kidney transplantation (also called renal transplantation) is the a process of transplanting a healthy kidney to a patient who is experiencing kidney failure commonly known as End Stage Renal Disease (ESRD). This is a permanent condition which completely impairs the functionality of a persons kidneys and dialysis has to be performed to filter blood. The transplantation process requires a surgical operation in which case a healthy kidney is implanted to the patient’s body and it thus assumes the roles formerly played by the failed kidneys. Normally, the failed kidneys are left in place though they have no responsibility.h9991470_001_1

Need for kidney transplant.
The basic work of a kidney is to filter blood and form urine from excess water and waste products found in the blood such as excess minerals.
When a person experiences kidney failure, it means that both kidneys are not filtering blood. This risks the person to have excess toxic waste in one’s blood. If not watched out or addressed this could turn to a series of other health complications and it’s potentially fatal.

Factors contributing to renal failure.
Most kidney failures are a result of other medical conditions e.g. diabetes. When a patient develops kidney malfunction one is first subjected to clinical dialysis. This is an artificial mechanical filtration of blood to remove the toxic waste products and excess any water from the blood. There is a regular period for dialysis normally a week or per the recommendations of a clinician making the whole process costly. This process can be continued for the rest of the life but is not a sustainable solution. Hence the need for a kidney transplants. Transplants are more favorable because they provide the solution needed to filter blood and enable the patient to live a healthy and normal life with less complications or having to shield the burden of expensive medical costs of dialysis.

The kidney to be transplanted can come from a living donor or a deceased donor. The kidney donor and the recipient must be compatible to avoid the recipient’s immune system from rejecting the kidney transplanted.

Logic Behind Kidney Transplant.

How the kidney Works.

Dialysis

Dialysis

A human body needs food for growth and development and for the overall sustenance of the body. When one takes the food, it is broken down and nutrients derived from the food which in turn are converted into energy required by the human body. The body will then take in the nutrients that it requires and the excess is just waste which are left down in the bowel and blood.

 

In the human body there are kidneys which work together with the urinary system to keep chemicals (such as sodium & potassium) and water in balance, and remove waste called urea from the blood. Urea is produced when protein foods are broken down by the body. This urea is then carried by blood to the kidneys which have a mandate to remove urea which is a waste product and ‘clean’ the blood.
The kidneys will remove this urea from the blood by filtering it through some small units found in the kidneys called nephrons. Nephrons comprise of a circular ball of small blood capillaries, called glomerulus and a small tube called a renal tubule.
Now, urea, excess water and other waste products form the urine as these products pass through the nephrons to the renal tubule of the kidneys.Screen Shot 2012-04-02 at 8.23.25 PM

 

Can a Human Survive With no Kidneys?
As you have seen, the work of the kidneys which work together with the urinary system is to filter out the waste products and pass them out thus leaving the blood “clean”.
Now in the event that the kidneys get injured or diseased or malfunctioned in any manner, then the human body will experience a lot of difficulties trying to get ride of the waste products. A means of removing the waste products from the human blood has to be devised and that leads to the dialysis process. Dialysis is an artificial process through which waste products in the human body are extinguished. The process is done to patients whose kidneys have malfunctioned and can’t carry out the process.
The process of dialysis seems not to be a favorable solution, Why?
The human body has to keep supporting it’s life by the intake of food and water. We have discussed the process whereby the excess water and nutrients in the food are broken down are passed in the blood stream and need to be removed from the blood system. This means that the process is a recurring one and has to be done time and again on a regular basis. Then if the process of dialysis has to be employed in the case of failed kidneys, then the process should also have regular schedules.
This means that the process will not only be cumbersome but will in the long run become so expensive and probably uncalled for. These limitations of the use of dialysis in the case of failed kidneys have led to the need of a better solution for the process of removing the waste products from the human body.
The better solution to all this is the need for a kidney transplant, which is a better and more permanent solution although it too got it’s own setback such as in the likely event of the kidney rejection by the patients body.